There have been several questions about surgery/anesthesia and PD. Here are some quick and dirty references (there are likely many more but I have neither the visual stamina nor the web search skill to find much more !) Severn, AM Parkinsonism and the Anaesthetist Brit J Anesth 61: 761-770 1988 Stack, C et al MAOI and Anaesthesia BJA 60:222-227 1988 Weinberg, S Neuroleptic Malignant Syndrome Anesth@Analg 62:848-850 1983 Reed A Intraoperative Exacerbation of PD Anesth@Analg 75:850-853 1992 Muravchick S PD Symptoms during Emergence from General Anesthesia Anesthesiology 82: 305-307 1995 Browne B MAOI and Narcotics Brit JPsychiatry 151;210-2121987 Lecrubier Y Risk Benefit assessment of MAOI Drug Safety 10:292-300 1994 Zornberg, G Severe adverse interaction between demerol and selegiline Lancet 337:246 18991 Wells DG MAOI Revisited Canadian J Anesthesia 36:1 1989 Roizen M MAOI J Clin Anesth 2:293 1990 There are other references of value at the end of these papers. Ken Janis