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Dear All, My mother (PD, 89) takes Sinemet (regular) and, for a moderately sluggish intestinal tract, Lactulose. I recently learned that Lactulose is largely lactose, which is a sugar. That it is largely sugar disturbs me, as I understand from various health professionals that sugar generally can have a deleterious effect on the immune-system, among other things. It also, various health professionals say, can quickly make a person tired (beyond what may be an initial boost). Now I've seen some posts here in the PD Digest, in which the issue of tiredness is popping up. I would therefore like ask the following: (1) Has the problem of tiredness, or weakness, that has bothered any PDers, seemed (if you think back) to be linked in any way to the ingestion of any form of SUGARS? (This would include table-sugar, syrups, sweet fruits, Lactulose, etcetera)? Also, since carbohydrates are transformed, by enzymes in saliva etcetera, into various forms of sugars, has anyone noticed whether this tiredness or weakness may be correlated with the ingestion of CARBOHYDRATES? (Note that many foods -- particularly starch-based, such as pasta, or breads, for example -- are loaded with carbohydrates). (2) Have any of PD's OTHER symptoms (tremors, dyskinesias, etc.), to your knowledge, possibly been linked to the ingestion of SUGARS, CARBOHYDRATES, or a sugar-containing medication such as LACTULOSE? (3) If you HAVE found such correlations, what ALTERNATIVES have you tried that may have gotten around these problems, and how successful were those alternatives? -- SJS