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I am writing to see if anyone else has experienced what my father has. He was diagnosed with PD about 3 or 4 years ago. He has taken- Sinemet, Permax, Primidone, and a few other combinations of drugs throughout the past years. Not one single drug or combination of drugs has alleviated any of the symptoms of his PD. I suggested that he see another doctor, and he went to a clinic in Rochester, NY. They said he has PD, and tried him on Primidone, and no change. He is only 56. Has anyone else experienced this? Have any suggestions? Thank-you for your time!!!