On Tue, 11 Feb 1997 15:36:34 -0500 Bill Bell <[log in to unmask]>
writes:
>Friends,
>Could someone pleasee let me know the half life of Sinemet CR and what
>that actually means. How long is it generally effective, etc.
>
>Also, has anyone had any experience with Paxil as an antidepressent.
>
>Thanks in advance and best regards\
>
>Bill
>--
>Bill Bell ([log in to unmask])
>
Hi BIll,
On Sinemet CR:
I am posting this to the whole list, hoping that this account of
how Sinemet CR tends to work in me may be useful information for others
besides Bill.
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I think in terms of "How many minutes of relief will I obtain
by taking CR tablets?
And secondly, what quality of relief does each tablet provide?
In my body,(as you know, each person has a unique response) one
100 mg. Sinemet CR tablet (the pink one) lasts me about 90 minutes. A
200 mg Sinemet CR tablet (cafe-au-lait ) lasts about 180 minutes.
So, I can think in terms of 0.9 minutes of relief for each 1
milligram of CR swallowed.
However, the 200 mg. CR tablet tends to give me dyskinesia after
about an hour. I think that once it starts dissolving, too much medicine
is hitting me all at once.
. So I have learned to divide the 50/200 CR along its crease,
ending up with 100 mg. This half-tablet still seems stronger than the
pink 100 mg. tablet. It also seems, generally, to last a bit longer,
maybe up to 120 minutes. Usually, neither CR pill is as strong as the
effects of the conventional, lemon-yellow 25/100 tablet.
Both can at times leave me slightly undermedicated. So I have
to nibble or take bits of a conventional yellow 25/100 along with
taking the CR, to jump start my body until the CR tablets take over.
If Sinemet CR kick in perfectly, it's sort of like a
cruise-control button in a car.
You sit back and relax. and go for a really nice ride.
Sometimes, the CR doesn't work AT ALL.. The shiny sealed surfaces
seem to act like a barrier to the L-dopa inside the tablets. Then I
feel like I'm stuck in a tar pit, and can never really get free to move
normally.
CR is sometimes helpful to me during the night, and is used up
slowly enough to help somewhat , with sleeping longer.
Dr. Abraham Leiberman wrote an excellent and detailed report on
Sinemet CR about 5 years ago. IF you call the APDA at 1-800-223-2732, I
think a copy can be mailed to you.
Ivan Suzman
Portland, Maine land of lighthouses
