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Michelle; From my reading and research, the Carbidopa in our Sinemet takes care of small amounts of B-6, just as it does small amounts of protein, by keeping the levodopa intact until it gets across the brain barrier where it triggers dopamine formation. B-6 and protein being amino acidic in nature rival levadopa in the race across the brain barrier before being attacked by digestive components. That's loosely explained as I see it. Anyone to elucidate? [log in to unmask] (Mary Manfred