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A cold big toe could also be related to nerve damage in the lower back,(say from a prolapsed disc) which is pressing on a certain nerve. I know from experience that damage at certain levels does indeed produce pain and numbness in one side or other of the foot, also up the leg. Can't be specific, my notes are not to hand. My husband complains of HOT feet, and they are often red. We understand this IS a PD symptom, and often the redness and a particular blotchiness can be due to amantadine. Great in winter! Not so good in summer! Joy Graham >. Just lately he has been complaining that his dress shoes are >> not comfortable anymore and that his big toe is cold and numb. He is >> thinking it may be Reynaud's Syndrome and I am thinking that the PD is >> speeding up. >> Maggie Salls > > >Your friend should check with his doctor concerning this foot problem. If >his big toe is *cold* and numb there is a possibility that it is, indeed, a >circulatory problem. I'm not familiar with PD acting in this fashion - but >I've seen more than a few folks with arterial spasm or occlusion who voice >that complaint. >------ >Mary Ann