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Hi. I am 49 years old I live with PD since I was 30. I have been depending on Modopar (the French Sinemet) for 14 years up to now. I was taking also Parlodel but had to quit this last medication because of very unwanted side effects. Then, for the last 3 years, I have to manage the feeding of my brain with only one medication : Modopar. Starting 3 years ago with 12 (100+25) doses a day and 20% " ON time " (that was a very poor score), I am now scoring more than 80% " ON time " , NO dyskinesias, with only 6 (100+25) doses a day. In order to achieve that kind of quite a good result, I am also using a computer program to evaluate the optimum tablet strategy. This program can't be dispatched because it has not yet been written in order to present a good portability. Each dose of Modopar is taken into account using the signal processing notion of Impulse response. i.e. : represented on a time scale, as it appears to the brain. >From the time the dose is taken, the level of available Dopa increases for 1.5 hour. Then, the level is constant for only half an hour and decreases. The duration of the first two parameters is independent of the kind of tablet The amplitude that is reached is 9.8 with non CR tablets, against 5.2 with CR tablet. But the duration of impulse response of CR tablets is longer. The level is divided by two 1.5 hour after the start of the decrease with non CR tablets against 4 hours for CR tablets In my model, the surface of a 100+25 CR (Modopar LP) impulse response is the same as those of a (100+25)non CR Tablet (Modopar Dispersible). It seams to me that: 'bio-availability'. describes the fact that the level that is reached with CR tablets is lower. But don't forget that it lasts longer. Although it is more difficult to control the time at which the rise time starts when tablets are gelules (sorry, I ignore the word that you are using for it in your funny language ). MEG