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Hi Brian I paid a visit to Ronald F. Vetter <[log in to unmask]> 's WEB site " http://www.ridgecrest.ca.us/~rfvetter " and from there, using " Brian Collins " link, I got a very pleasant trip to your model description. You certainly are ahead of me using pharmacokinetics. I'm certain that we are working on the same wavelength. In the model that I'm using, the way doses are fading is described using the decreasing part of a gaussian distribution. i.e. the impulse response of a Modopar dose, is computed using the following Excel Formula : IF(h-t<0;0;IF(h-t<=m;a*(1-COS(PI()*(h-t)/m))/2;IF(h-t<m+p;a;a/EXP((h-t-m-p )^2/d^2)))) Where : " h " is the current time " t " is the time at which the dose is taken " m " is the rise time (1.5 hour) " p " is the duration of the constant level (0.5 hour) " d " is the width at half level of the gaussian distribution whose center occurs at the time = t+m+p d = 1.5 hour for non CR doses an 4 hours for Modopar LP doses for memory, respectively a= 9.8 and 5.2 This modelisation gives a very good representation of what the available Dopa is proportional to. It allows me to predict what is going to happen in the near future (with a +/- 5 minutes accuracy) knowing the state in which the previous dose has worked. MEG