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Hi "(Jean) (Hayes)" <[log in to unmask]>, you wrote >Hello. My name is Jean([log in to unmask]) and I just joined you. You all >seem so knowledgeable and technical, I am sure this is a level above me. I >was just wondering if anyone else takes one tablet of Sinemet CR 25/100 four >times a day and if they also get kind of wild toward the end of the four-five >hours. It doesn't necessarily happen only at the end, but often it does. I >also experience some rigidity that is more than just uncomfortable. Anyway, >in simple terms, just wanted to know if this is typical of PD. Thanks for >listening. All sounds pretty familiar to me! Uncomfortable, even painful, rigidity as the meds come to their end is something I especially suffer. -- Jeremy Browne - [log in to unmask] Shaking Hands BBS - +44 (0)1252 626233 - Fidonet 2:252/160