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I am wondering if anyone else has had a similar experience with the use
of amitriptyline and the subsequent "weak legs".
--
Bill Bell ([log in to unmask])
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From: "E. Jack Savely" <[log in to unmask]>
Subject: Re: Weak legs, agonists
Bill:
Your step-father's problem sounds like my father-in-law.
He is a 'worrier' type person. Has been all his life. If
there isn't something ready to be worried about he'll
manufacture something. Nicest guy in the world but has
this problem.
When he began taking an antidepressant the world became
less worrisome. However, when changed to amitrypteline
he also complained of weak legs. Sometimes it gets so
bad he can hardly stand.
While amitrypteline doesn't report these type of side
effects in its literature, there must be something in
some people to cause this situation.
I doubt that it has anything to do with his Sinemet but
stranger things have happened in individual cases. My
FIL doesn't have PD.
In your mother's case, I find it strange that the Sinemet
dosage wasn't altered when Permax was introduced. I'm not
surprised at the nausea and other symptoms. Some people
have difficulty in tolerating Permax and Parlodel. My wife,
Jeannette, takes Parlodel and we reduced her Sinemet
substantially when Parlodel was introduced in 1982. Also,
she was placed under continuous surveilance when started
on Parlodel. Fortunately Jeannette didn't have any great
problems accepting the drug.
An agonist essentially is designed to help the levodopa
reach its intended location in greater quantity. I view
them as road pavers laying asphalt down to allow the
levodopa car to travel at greater efficiency to a desired
location. It doesn't bolster the effect but rather allows
more of the Sinemet to arrive at the brain which will cause
the need for less levodopa if the agonist does its job
properly.
According to my RX info, introduction of Permax or Parlodel
needs to be watched if the patient is using any medication
for depression or psychosis.
I don't envy you your postion in caring for several elderly
persons with physical problems. It's a heavy load.
Best wishes.......Jack
***********************************************************
E. Jack Savely [log in to unmask] Topeka, Kansas
CG - Jeannette 58 - 20 Starliter on Chat
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KANSAS - 'THE WHEAT STATE' HOME OF THE SUNFLOWER AND 'TOTO'
Ad Astra per Aspera - 'To the Stars through Difficulty'
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