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On Tue 25 Feb, Donovan White wrote: > I've already mentioned on this list that my mother (67, diagnosed 3 weeks > ago) was given Sinemet 25/100 3x/day and has not seen any results. She > takes it about 20-30 minutes before meals and restricts her protein intake. > Her doctor started her on an extra 1/2 dose along with the original dose. > She's been on this for about 3 days and still hasn't seen results. She has > an appointment with a specialist March 13 and feels comfortable waiting > until this time to bring up the fact that the extra dose hasn't produced > results, either. Again, she is, according to her first doctor, rthe neuro > who diagnosed her, in the early stages of PD. > > What I'm wondering is -- does the failure to get results with this dosage > strongly suggest that she doesn't have PD but something else?? > > Her symptoms seems so typical (if you can even say that). According to > everything I've read, it seems like PD (of course I haven't read a lot > about conditions similar to PD): off balance; slowed speech; cannot really > use left hand; classic PD gait; slowness in moving and turning around. > > Any thoughts on this?? Again, my main question is, should this current > dosage work if it's PD?? > > Thanks, again, for all your knowledge and help. > > Debbie White > > > > [log in to unmask] > > Hello Debbie, I must admit that it is beginning to look as though your mum does not have simple (!) Parkinsons Disease. You have not yet proven the case - it could be that your mother needs mor levodopa than some people to ensure that some gets through to the brain. I would expect your specialist will comment on that. My decision point would be about 200 mg in one dose, three times a day. If that does not produce a reaction, you might have to look elsewhere, and I will make another entry in my 'so you think you know about PD?' file. Regards -- Brian Collins <[log in to unmask]>