Attached is an abstract of a recent patent application for a method of
getting compounds across the blood brain barrier. This would seem to have
some important implications to us all.
Ron Reiner
-----------------------------------------------------------
Method to enhance permeability of the
blood/brain blood/nerve barriers to therapeutic
agents
Source: MicroPatent
MicroPatent via Individual Inc. : Abstract: A method is provided to
enhance the ability of a neurologically active compound to penetrate
the blood nerve barrier (BNB) or blood brain barrier (BBB), by
administration of a conjugate comprising the neurologically active
compound linked to a carrier molecule that has been shown to have a
substantial permeability coefficient across the BNB and BBB.
Ex Claim Text: A method to enhance the ability of a neurologically
active compound to penetrate the blood nerve barrier (BNB) or blood
brain barrier (BBB) comprising parenterally administering to a mammal
in need of treatment with said neurologically active compound, a
conjugate consisting of an effective amount of said neurologically
active compound conjugated to a carrier molecule with a substantial
permeability coefficient across the BNB or BBB selected from the group
consisting of hemoglobin, lysozyme, cytochrome c, ceruloplasmin,
calmodulin, ubiquitin and substance P. ceruloplasmin, calmodulin,
ubiquitin and substance P.
Patent Number: 5604198
Issue Date: 1997 02 18
Inventor(s): Poduslo, Joseph F.Curran, Geoffrey L.
If you would like to purchase a copy of this patent, please call
MicroPatent at 800-648-6787. [02-26-97 at 15:17 EST, Copyright 1997,
MicroPatent]
