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on " Thu, 27 Feb 1997 ", : Ron Reiner <[log in to unmask]> wrote ----Does a healthy SN produce dopa at a constant rate all the time ... Or does it sometimes turn off, slow down or increase the flow? Does the SN simply try to keep a fixed concentration of dopa in the brain?--- I think that you have " mis le doigt sur le vrai probleme " (put the finger on the real question). I am a 49/19 PWP. For 3 years, I have been using only one medicatication : Modopar. Trying to keep the level of L-dopa as low as possible and to understand what dopa is doing to my brain. My opinion is : 1 -if a constant level of dopa was necessary in order to have our CNS to work properly it would have been simpler to have the concerned neurons directly (electrically) connected. 2 - I feel like dopa is needed only for some kind of tuning. Something like a correction of differences in proprioception signals coming from the left hand side of the body vs. information coming from the right hand side. Once this tuning is made, dopa is needed in order to keep the temporary connections at work. The tuning I am speaking of is made when the level changes. It can be achieved when the level of dopa is increasing or when it is decreasing. The problem that has to be solved is to identify the time at which the level of dopa has to be modified. MEG