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Hello Kurt, About three years ago I began to liquidfy my sinemet upon recommendation of my neuro who is Dir. of R & D for the Foundation. 3000iu of Vitamin C was recommeded whether as Liquiid Sinemet (LS) or in other forms. Both C & E are thought to slow down the progression. At that time I was on 25/100 which has been reduced to 10/100's My symptoms at that time as toe and foot cramping, slight tremor and slight freezing. I underwent a single Pallidotomy last February and the cramping ended immediately. The tremor has since dissapeared (not from the "P") but my PD settled in my legs. I now suffer a great deal of my life from freezing and gait problems. In any case, liquifying the sinemet has smoothed out my ON/OFF's. (DISCLAIMER) this formula was prescribed for me. This posting is not inteded to offer the same results to anyone else. Please consult with your neuro before trying anything new) I take 13 X 10/100's and dilute them into one litre 946cc of your favorite orange juice. (I might add that some brands and the choice of "from concentrate" or "100% caused some uncomfortable times due to too much acid...heart burn, excessive gas) If you find the same results you can reduce the OJ and replace by water but you should add some powered Ascorbic Acid to make up the difference. divide the number of hours (including a double dose for the first of the day) until the last one in the evening. For me this comes to 60cc/hour X 16 hours.= 960cc You should average to start one dose of Sinemet to 100 CC's OJ you can see my dosage increased somewhat good luck and report back to the group because many of us have already switched and many more are considering it. Joyce