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Joan, I took amantadine and eldepryl for about 6 months (before I began taking sinemet). My neurologist is from the Mayo Clinic in Rochester. He told me it would not be effective very long--it wasn't, about 5-6 mths--but that it would be a means of delaying the taking of sinemet. I was 52 when I developed the symptoms of PD, and the taking of amandatine was about 3 years into the treatment. The only side effect was that it discolored my flesh around the right ankle--it turned a light purple. My doctor indicated that this was a possible side effect, and it is also cited in the PDR as a possible effect. It's amazing that you've been able to go for 8 years without taking sinemet. Good luck. Howard Cohrt