Anne Livak <[log in to unmask]> Subject: Antioxidant Juice shortens off periods Hey folks, we're all desperate for magic and there is no magic. It's probably not the "magic"antioxidant in the juice that shortens off periods, but the presence of the acid and liquid promoting more rapid emptying of the stomach. [Sinemet is absorbed in the duodenum] as well as the mixing of the Sinemet with the juice that allows better absorption with a better on and less dyskinesia, as has been demonstrated for liquid Sinemet. [i.e. taking juice + Sinemet may be almost as good as liquifying Sinemet in juice before drinking it] Jacquie Winterkorn, MD We could be close to a cure if more money were spent on PD research-- why is each patient with AIDS worth $1000+ and each PWP wlrth only $15 in research money? With disappointment and sadness I am taking a break from this List for a while . We do altogether too little of what we do best --that is, record and compare notes on the phenomenology of PD--, commisserate about how rotten this disease is, acknowledge to one another that we know we're still in there, but buried in these stiff, uncooperative bodies that people stare at in the supermarket when the fingers can't get the credit card out fast enough at the checkout counter, that stupid bank clerks ask for a doctor's note, and that telephone operators accuse of drunkenness when we cant articulate because we're racing on medication touted as a cure, but with which each of us is sluggng it out in our personal hells. I was hoping to hear the personal experiences of PWP on things that we have no scientific data on -- like reports of :-diurnal variability before beginnng Sinemet?; -PD doing worse or better on estrogen replacement? -how much extra Sinemet do you need to eat a steak vs fish without crashing at the dinner table? -more on the end-of-dose dyskinesias. -should we be driving Instead, there are a couple of people who insist on spouting pseudo-scientific nonsense, 19th century, half-baked, incomplete, wrong, misleading half-understood , oversimplified neurobiologic theories in these e-mails and it is driving me up a wall. DA metabolism...over supplies undersupplies and downregulation... electrical activity...pharmacodynamic formulas . There is so much misinformation slung about in any one day here, that with my PhD in neuroscience I wouldn't know where to begin to correct it. And pray tell, what are the research and educational credentials of our resident theoreticians?? Did they ever consider taking a neuroanatomy book out of the library and looking at the relationships among the substantia nigra, globus pallidus, caudate nucleus and then sorting out what is known about the neurotransmitter circuitry? Go back to high school physiology and look up neurones, dendrites and axons, action potentials, chemical and electrical activity, and concepts like inhibition, disinhibition, and deafferentation or denervation suprasensitivity? [denervation suprasensitivity is a likely contributing factor to why we become hypersensitive to DA; disinhibition results from loss of inhibitory circuits and contributes to our dyskinesias]. A few selfish people are ruining a great thing... I work for a living and PD slows me down so that I feel on the edge all the time. The PD "information" exchange is taking more time than it is worth. You can still call on me if I can help in any way.