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Dennis Greene wrote: Brian, The quote is accurate but incomplete. It was originally proceeded by the words " With regard to Sinemet CR ---". In Ernie's earlier posting, he said: >Seeking clarification on the "half-life", I was told that the "exponential >decay rate" referred to the drug once it was in the blood plasma. and later >Sinemet CR will,however, deliver its designed dosage evenly >per hour until exhausted. At this point, the half-life decay rate >will again come into play for the drug remaining in the blood. I seems to me that as each of CR's deliveries arrives in the blood plasma the half-life decay rate will apply to it. If this is indeed the case (a phrase I used in my original posting) the slowing down of the decay rate will result in each new delivery of levadopa being delivered on top of the exponentially decaying residue of the previous deliveries resulting in a (probably) small increase in the drug levels over the life of a CR tablet. Dennis. ++++++++++++++++++++ Dennis Greene 47/10 [log in to unmask] ++++++++++++++++++++ ---------- > > > Dennis whrote > > > > > > 1. the exponential decay rate is operative on all deliveries of the > > drug, once they are in the blood stream. > > 2. this in turn will result in a small, but significant increase in the > > drug levels over the delivery period of the tablet, culminating in a peak at > > the end of the dose. > > > Dennis, That would seem logical and it is supported by the fact- whether using CR or regular Sinemet that for many of us Dyskinesia increases later in the day as the blood level builds. Charlie -- ********************************************************** CHARLES T. MEYER, M.D. MADISON, WISCONSIN [log in to unmask] **********************************************************