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On Sun 02 Mar, George M. Andes wrote: > For those who care, a first try at a complex problem; for those who don't, an > > exercise with the delete key: > A Very Simple Model of Drug Build-up in the Bloodstream. Hello George, Your equations are fascinating, and very much in line with some equations which I put together a while back, but I am sorry to say that my rusty maths prevented me from following through to the final solution. I was trying to explain the fact that measurements of blood plasma concentration charting the life history for a Sinemet tablet tend to show a linear ramp up to a peak level, followed by a (shallower) ramp down to zero, whereas the shape of the response curves that I get from my Analysis Program are much more rounded. Asuming for the moment that my curves are representative of what the brain actually experiences, I concluded that the differences between the two traces may well be due to a delay associated with transmission across the blood/brain barrier, which could be represented by an exponential equation as shown on my charts. They match beautifully with your equations. Please transmit a set of your charts to me. (I find that GIF format gives the best reproduction). I will send copies of my charts to you separately to avoid overloading the system. Regards -- Brian Collins <[log in to unmask]>