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Charley wrote > My Neuro's opinion is that > younger patients should postpone the use of Sinemet, if possible, and > later minimize its use. Keeping off L-Dopa for as long as possible has been my strategy for the past five years, based on my early readings, some excellent YAPP&RS seminars, discussions with other early onset Parkinson sufferers and last but not least this list.My consultants don't disagree and to be honest I dread the thought of the potential side effects. Which is worse; stop or go?? But now the tremor is getting worse; holding a cup of tea in work meetings is "challenging" [I can't cock my little finger :-))] and stand up fork buffets are a "nightmare" [How do you hold the plate, the glass attached to the side, and eat? Answer : I don't :-(( ]. And writing on a white board? No chance! And my speech is getting quieter and the mind getting slower, I think ? So! Do I go for this "miracle cure", which may have no serious side effects for 5 - 10 - longer(?) years. Will I recover my confidence and standing at work? It is my choice, I'm in control ;-) Answers on a postcard to me :-)) Best wishes to you all Bob 45/5 Leeds, England