My experience with Eldepryl & Amantadine, later supplemented with Parlodel, over several years, is that they brought me immediate & continuing help with tremor, but only modest help overall. My experience with Sinemet over only 4 months is that it brings dramatic improvement! I would advise that all PWP are different, but Sinemet has taken me back to a physical condition that existed before symptoms appeared, well before diagnosis. I accept my Neurologist's advice that younger patients postpone the use of Sinemet, if possible. However, Sinemet's benefits should be recognized. I think that sometimes PWP get use to feeling miserable unnecessarily. Right now my daily medications are Sinemet 50/200CRx2, Eldepryl 5mgx2, Amantadine 100mgx2, Parlodel 2.5mg 3 or 4 per day depending on how I feel. Before adding Sinemet, I was taking Amantadine x3 and Parlodel x6. I felt "wired" in the evening and had difficulty sleeping before reducing Amantadine & Parlodel and adding Sinemet. I now sleep well for about 6 hours, but am very stiff upon rising, before taking Sinemet & Eldepryl with orange juice. A continuing problem that I believe is caused by Parlodel is hypotension, leading to cold hands & feet. I believe that these meds reduce my need for Sinemet. Recent research suggests that Amantadine may have protective benefit (Scientific American January 1997). Charley Countryman (46/6) [log in to unmask]