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Thanks for any advice given, My sister began a trial course of Sinemet two weeks ago. She is newly diagnosed and had the following symptoms; walks with head leaning forward, writing very slow, moves and does everything slower, has a frozen shoulder on right side (is right handed), neck stiff,right ankle arm and wrist stiff, slight tremor in handwriting some internal tremors in leg and lower trunk while in bed at night. MRI and blood work normal. Had extreme nausea on beginning Sinemet and needed addition of carbidopa and take with meals to tolerate. She feels no clear change of symptoms since starting on the Sinemet... and since this was to be a trial to see if she had Parkinsons...the question is should she any changes? ...Does she have Parkinsons?... Should she stay on Sinemet? Thanks in advance for taking to time to respond...Gail email address... [log in to unmask]