Joao, Your question why not only Sinemet is interesting. However, I see the group using only Sinemet as another possible solution to the experiment of treating PD. I see my Neurologist's recommendation as another possible solution. With this particular problem, PD, I think that there are probably multiple causes behind the loss of dopamine in the substantia nigra and the striatum. This suggests multiple solutions to me. I don't believe that my Neuro. looks at me as a subject for experimentation. But I like to look at myself as a subject (in a positive sense). It makes having PD more interesting. My Neuro's opinion is that younger patients should postpone the use of Sinemet, if possible, and later minimize its use. Maybe because he's Board Certified in both Neurology and Psychiatry, he did a good job explaining to me his reasoning. (From what I've observed on this list and elsewhere, many other Dr's don't seem to do a very good job of explaining medications to their patients.) He also, to a great extent, left it up to me to decide when I was ready for Sinemet. So I have taken my Dr's opinion as a hypothesis to test. Will using different combinations of other drugs before and along with Sinemet be an effective long term treatment for PD (for me)? I don't know. I'm not yet ready to change my little experiment though. I'm expecting that it will lead to some dark places to explore along the way as the disease progresses. But it should be interesting to continue to share my experiences with others on this list. Sincerely, Charley Countryman (46/6) [log in to unmask]