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From:  Byron, Sara
Sent:  Tuesday, March 04, 1997 9:48 AM
To:  owner-parkinsn
Subject:  RE: Migraines and question on Amantadine

Our experience with amantadine and sinemet were mixed.  Amantadine played
a role in controlling dad's shaking and tremors.  he used it for many
years.  As the PD progressed, however, the associated PD dementia
increased to an intolerable level.  We faced a permanent nursing home
decision if the dementia could not be controlled.  Our new neurologist
proposed discontinuing the amantadine, as it can build up in the system
adding to the dementia.   We started weaning in early AUG 96., and the
process didn't end until Nov.  This was a terrible period for us as there
were SERIOUS withdrawal problems - freezing (and I mean life a 150 pound
rock - Mom and I swore that his feet grew roots into the ground)
 falling, hallucinations, anxiety attacks, perceived breathing problems,
blood pressure swings.

The lesson, I guess, is that this drug has its place, but should be
monitored closely and carefully.  BTW - Dad is shakier now, but the
dementia is under control and he is still at home (with home health
assistance, of course).  We still take things one step at a time!

Sara Byron
daughter of Richard 79/28 yrs w PD ( and counting!)
Hinsdale & Naperville, Illinois



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