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This is a lengthy message but I must cover anticipated questions to narrow the responses. We have had a very hard ten months--almost a year since Hytrin was prescribed for my husband's slightly enlarged prostate. Hytrin is also prescribed for reducing high blood pressure and used apparently successfully. But I am interested in cases of persons who have been on Sinemet and/or Eldepryl and also HYTRIN and have had side effects. The last week in April, my husband was prescribed a small dose of Hytrin for seven days and then he was to take 500mg for three months. The night he took the first 500mg, he woke me and said that he had been walking the floor for two hours, that something was happening in his brain and that he could not describe it but that he was afraid that he might die and PLEASE call 911. I took him in and emergency observed him for a couple of hours, said that it would wear off...didn't know how long it would take. He never took another Hytrin, and never will, but the next night he had the same thing happen but only at intervals. He insisted on going back to emergency. My husband is not easily alarmed so this had to be serious. EM. treated him the same as the night before: observed him, made sure it was not a heart problem, and said that it would have to "wear off." He has not been the same since. For the months of June and July there were trips to the regular neurologist & emergency calls when he was a nervous wreck. The sinemet was decreased and changed. Over that two month period his condition changed from a moderate PWP to an advanced case. The first week after taking Hytrin we walked into the neurologist office and he had to ask for a place to lie down while waiting. He was so weak that he could not walk more than 30 steps without help and then collapse. Before that he was a normal person and I hardly thought of his PD. He regularly attended the church meetings, helped with the youth program and held the office of church clerk which meant typing the minutes. He cut the grass and took care of all jobs around the house as well as his own personal needs and all the finances. Besides that, he did all the driving for us and his 91 year old mother. The neurologist says it was the hytrin; the urologist who prescribed the hytrin says that it was the sinemet (and I agree that it was probably both.) There is more to my story which is almost devastating since I had to quit work, sleep patterns have only recently had relief, my back and hips are having feeling that I have never had before, and he needs constant supervision. On August 1st he spent seven hours in emergency after a phone call to the doctor because of extreme nervousness, shaking, and begging for help. The neurologist on duty changed his sinemet and sent him home. Aug. 2, the psychiatrist prescribed Trazadone because we had had no sleep except for cat naps since the hytrin. His diagnosis was that he was depressed. ( I said that he was extremely tired and confused as he could not even calulate three or four hours to the next medication.) I cut a bit off the 50mg tablet of Trazodone(Desyrel) and the next morning he was in the psychiatric ward, "psychosis--harmful to self and others." He was there 33 days. ECT was discontinued after three treatments because it was evident the hallucination were worse. One week after administering the wonder drug, Clozaril, he returned home. On clozaril, he was like a drugged person so after 25 weeks, I asked to take him off and as we brought the dosage down from 87mg to 25, each reduction showed awareness. He has changed to a well known Parkinson specialist, Dr. Lewitt, Sinai Neuro-Science Center, W. Bloomfield, MI and he is now taking Sinemet 25/100 at 6 , 10, 2 & 1/2 at 6pm. Amantadine at 6 & 10am. One CR 50/200 at bedtime. The psychiatrist has him on 200 mg of Serzone twice a day. We have had three therapist. Since taking the CR and Serzone at bedtime, we see improvement with sleep (about 3 or 4 hrs, uninterrupted, some nights). So you see why I write to you who are friends already. I joined you March 5.. I foresee no more vacations. Home is the only comfortable spot. Eating out is stressful for him. The "Physicians's Desk Reference" does not offer any cautions for Hytrin or Trazadone, yet two doctors (unrelated to the case) have indicated both. His regular doctors are all connected to the large university hospital so I cannot expect any blame. Yet our lives have been drastically changed without notice. I am about resigned that the brain altering is permanent; however, long-term memory is Good; concentration is poor; NO reading; all senses are extremely sensitive; and physically, his PD esculated considerably-- overnight. (Yes we belong to a support group and one visting neurologist expained transmitter blockage. But I don't have the terminology and I don't know if it will repair itself.) So I write on behalf of an innocent person who cannot express this for himself. My sympathy is extended to all of you with PD and we are encouraged by your humor and strength and desire to help others. I have two questions of you brave comrades: Have you any similar experiences? How is the best way to have this documented so that others will not suffer from the same? Can two lives be changed drastically overnight without attaching responsibility? Their explanations are: "That's Parkinson's" If you choose, any responses can be sent directly: [log in to unmask]