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An interesting question regarding PAIN and PD was raised at our monthly PD support meeting today. Some PDers report little pain sensation, others report intermittent sensitivity. I volunteered to ask PARKINSN members, if you have PD or a PD+ do you have a high tolerance for pain after injury (cuts, falls, bruising, etc.)? Today, Dr. Jeffery Joyce, the PD specialist at the Sun Health Research Institute in Sun City, Arizona, presented an excellent slide show explaining the dopamine pathways and how the new PD drugs compare to c/l-dopa in affecting the D1, D2, and D3 receptors. During Q & A and discussion, he was unaware of the desensitivization to pain symptom. My aunt, who had PSP, had an extremely high pain tolerance. After a dead weight fall banging her head onto concrete, she'd deny falling and claim not to feel any pain. Later when I'd push on the big lump on her head, she admit she could feel it. She'd hardly wince when breaking bones, falling into cactus, or cutting herself. Before I intervened she lived alone and had 20+ lesions on her back from falls and cuts, none medically treated. To conserve listserv chatter, please reply directly to me. I'll post a summary of all responses in a few days, and I'll send it to Dr. Joyce and invite him to join our PARKINSN listserv. 0===================================================================0 | @..@ A.J. CONOVALOFF | | (----) "The Molokan Cyber-Cowboy" __o | | ( >__< ) PSP Support Groups of Arizona `\<, | | ^^ ~~ ^^ [log in to unmask] . . ..(*)/`(*) | 0===================================================================0