I just came back from a consult with Dr. Enrico Fazzini of New York for my mother. The Upjohn salesman was in his office as I was there. He told Dr. Fazzini that Pramipexole will be available in three weeks, and Dr. Fazzini gave me a prescription to give my mother's pharmacy. There also might be a slight delay from the time the drug is released by the FDA (in three weeks) until the supply reaches the pharmacy through their supplier. Dr. Fazzini told me that he had a munber of patients that were on the trial of Pramipexole, and that it worked better than Permax. He felt that 2/3 of the dosage of Pramipexole would be the correct dosage to exchange for a full dosage of Permax. So, for example, my mother who takes .75 mg of Permax 4 times a day (a pretty high dosage!), could start exchanging each dosage for .5 mg of Pramipexole. A "side effect" of Pramipexole, according to Dr. Fazzini, is an increase in energy (sounds good to me!). He said that those on Pramipexole feel the need for less sleep and have more energy throughout the day. He also said another 4 drugs should be released this year to help with Parkinsons. Let's hope Pramipexole works as good as advertised! Sheldon Rothman ([log in to unmask])