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Hi James, You wrote: > My question is this: does anybody have an explanation for this? Why must the > CR be taken whole? Sinemet CR is formulated as a Controlled Release (hence CR) tablet. The tablet dissolves slowly, releasing small amounts of levadopa over its life-span. By chewing the tablet you released the whole dose in one hit, making it in effect an ordinary Sinemet tablet. I'm thinking of writing a book called 'Things my doctor didn't tell me'. The only problem is deciding whether it should be published as a 10 or 12 volume set. *grin* Dennis. ++++++++++++++++++++ Dennis Greene 47/10 [log in to unmask] ++++++++++++++++++++