FDA Panel Backs Deep Brain Stimulator for Tremors http://www.reutershealth.com/news/docs/199703/19970317rga.html ROCKVILLE, MD, Mar 17 (Reuters) - The Food and Drug Administration's Neurological Devices panel on Friday voted 8-0 to recommend approval of an implantable device known as a deep brain stimulator that helps control tremors in patients with Parkinson's disease and essential tremor. The panel was split on whether the device should be implanted on both sides of the brain, citing a lack of data. The $10,000 device, called the Activa Tremor Control System, will be made and sold by Medtronic Inc., and will only be recommended for patients refractory to drug therapies for the conditions. The FDA does not have to follow the panel's advice, but usually does. Panel members said they thought results were more impressive in essential tremor than in Parkinson's. Even so, Dr. Mark Hallet, a panelist and clinical director of the National Institute for Neurological Disorders and Stroke, said that he felt "...the benefit is clear," for all tremors, outweighing any safety risk. Committee members were concerned, however, about the potential for intracranial hemorrhage during implantation. During trials that involved 418 patients, 13 had ICH. In addition, panel member Dr. Gilbert Gonzalez, a neurologist from the Mayo Clinic in Scottsdale, Ariz., said that he was not convinced that it was safe to implant a polyurethane device into the brain. With Activa, electrodes implanted in the brain -- usually in the thalamus -- are then connected to a pulse generator, which is implanted subcutaneously in the chest. Medtronic says that Activa is an option to drugs such as levodopa, and to surgical techniques such as thalamotomy. With the Activa system, there is little to no damage to the brain with implantation, according to Medtronic and to an FDA reviewer. And, patients can turn off the device at any time, by passing a hand-held magnet over the generator. This helps control side effects due to the impulses, which include paraesthesia, paresis and dysarthria. The firm presented data from two trials, both relatively small. All patients received an Activa implant, but patients and physicians were blinded as to whether stimulation was activated at time of evaluation. Panel members said they did not consider this a true randomization, but accepted the results anyway. In the studies, conducted in the U.S. and Europe, both Parkinson's and essential tremor patients had two-point drops on the four-point Unified Parkinson's Disease scale and the Tremor Rating Scale, said Medtronic clinical investigator Dr. William Koller of the University of Kansas. The firm studied 45 U.S. patients at several sites, all of whom received unilateral implantation. In the European study, 28 patients got unilateral, and 18 got bilateral implantation. Koller said that ,for many essential tremor patients, results were so significant that it was "...like pushing the disease back twenty years." An FDA medical reviewer said that, at every follow-up point, 57.7% of essential tremor patients had at least a two-point decrease on the symptom scale. For Parkinson's patients, at least 60% of patients had a similar drop. The reviewer expressed concern that 7 of the Parkinson's patients had worsening tremors, and that most did not experience any improvement in other symptoms, or in ability to carry out activities of daily living such as bathing. But Medtronic and some panelists pointed out that tremor is only one symptom of Parkinson's and that Activa was not designed to address any other symptoms. Activa is already approved in Europe, Australia, and Canada for use in both essential tremor and Parkinson's. - Westport Newsroom 203 221 7648 --------------- New Brain Clue to Making Choices http://www.reutershealth.com/news/rhdn/199703/1997031310.html NEW YORK, March 13 (Reuters) -- Scientists may have come close to understanding a biochemical process in the brain that influences the ability to make the right decisions -- to predict what behavioral choices may be most useful for survival. A series of experiments on monkeys reported in the journal Science indicate that brain cells which secrete the neurotransmitter dopamine play a key role in this process, signaling the best course of action for a given situation. The new explanation for how people come to read sensory clues around them and choose from a number of behaviors for maximum benefit are based on more than 15 years of primate experiments in Switzerland, says Dr. P. Read Montague, professor of neuroscience at Baylor College of Medicine in Houston, Texas. In these experiments by Montague's co-author Dr. Wolfram Schultz of the University of Fribourg, electrodes were attached to the brains of monkeys to record electrical activity in dopamine-secreting brain cells (neurons). The monkeys were trained to press a level in response to a certain pattern of light to receive a reward (a squirt of juice). "And the electrical activity in these neurons is known to reflect the delivery of this chemical, dopamine, to the frontal cortex. Dopamine is one of several neurotransmitters thought to regulate emotional response, and is suspected of playing a central role in schizophrenia, Parkinson's disease, and drug abuse," Montague says. "We think these dopamine neurons are making guesses at likely future rewards. The neuron is constantly making a guess at the time and magnitude of the reward." "If what it expects doesn't arrive, it doesn't change its firing. If it expects a certain amount of reward at a particular time and the reward is actually higher, it's surprised by that and increases its delivery of dopamine," he explains. "And if it expects a certain level (of reward) and it actually gets less, it decreases its level of dopamine delivery." Thus, says Montague, "what we see is that the dopamine neurons change the way they make electrical impulses in exactly the same way the animal changes his behavior. The way the neurons change their predictions correlates with the behavioral changes of the monkey almost exactly." Montague and MIT co-author Dr. Peter Dayan pulled together Schultz's findings and created a mathematical theory based on the idea of those neuronal guesses and then compared it to what was actually recorded in primates. "It dead-on predicts the way those cells are going to fire," Montague says. The researcher notes further evidence supporting the theory comes from recent brain-scan studies of people who are missing parts of their frontal cortex. "They're missing the part of their frontal cortex that provides input to these dopamine neurons in their midbrain," says Montague. "And interestingly enough, these people lack the ability to make correct decisions about the future when you give them psychological tasks asking them that -- which is exactly what you'd predict from the way we construe these neurons." Montague says the findings in primates may also increase our understanding of the brain mechanisms affected by drug abuse. "This is an important piece of the puzzle because we know dopamine is involved in the same systems that are usurped by drugs of abuse, like cocaine." SOURCE: Science (1997;275:1593-1598) _/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/ _/ _/ _/ John S. 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