My husband is on sinemet and permex. Every time a new medicine is introduced, he takes a few days to condition to it. He usually hallucinates more (esp. at night, he may see people or things that are not there) or get a little more unstable in his walking. He is having good results on sinemet and permex. The two are given together often. Good luck with your mother, caregivers are very special to their loved ones. I think women with the disease are more independent, the men relying on their wives more.