There have been a number of postings recently relating Sinemet to fatigue. I think perhaps that we should look at this problem in the reverse order. I noticed that most, if not all, of the messages mention medication for depression; others describe symptoms which could be considered to be symptomatic of depression. One of the common symptoms associated with Depression is fatigue, with the patient spending far more time than normal sleeping or lying down. The reasoning that leads to a conclusion that Sinemet can cause tiredness seems to be: TakeSinemet. 2 to 3 hours Feeling low; tired Maybe Sinemet Feeling good. => --------------=>It's not time for----=> makes you tired later my next Sinemet yet I think it should be: Conclusion: I've got Sinemet is wearing Depression and my tabs TakeSinemet => 2to3 hrs -----> off: begin to feel are wearing off more Feeling good -------- bad: depression returns quickly later If the time over which thw Sinemet is effective begins to reduce, the best strategy is to go with the reduced time, rather than take a larger dose. Regards -- Brian Collins <[log in to unmask]>