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Debbie, As the senior citizens in my mother's neighborhood reply to the question of how they are today, "There are good days and bad days." That's especially true for us. Our meds are controlled by too many variable factors: physical health and well being (a virus or bacterial infection will cause them to not work as well), fatigue, stress, and the amount of dopamine our brain is producing on its own that day. It's an inexact science. After a while, you learn to treasure the good days and tolerate the bad. Good luck with your mom. Pat Schark pine`