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=46rom: Linda Carlton <[log in to unmask]> To: [log in to unmask] Subject: http://207.155.63.2/medscape/cgi-bin/taos_doc.pl?msw+0+med96-97+2142= 91+query+(reduced-glutathione) Date: Tue, 25 Mar 1997 02:44:37 -0800 [ Search and Display Medscape Full-Text Articles ] Please use your Browser's 'BACK' button to return to the listing Title: Oxidative stress and Parkinson's disease. Title Abreviation: Ann N Y Acad Sci Date of Pub: 1996 Ju= n 15 Author: Owen AD; Schapira AH; Jenner P; Marsden CD; Issue/Part/Supplement: Volume Issue: -HEADING- 786 Pagination: 217-23 MESH Headings: Animal; Cell Death*; Glutathione*; Human; Iron*; Oxid= ative Stress*; Parkinson Disease*; Rats*; Substantia Nigra*; Support, Non-= U.S. Gov't; -PG-; Journal Title Code: 5NM Publication Type: JOURNAL ARTICLE Date of Entry: 960819N Entry Month: 9610 Country: UNITED STATES Index Priority: 2 Language: Eng Unique Identifier: 96280968 Unique Identifier: 96280968 ISSN: 0077-8923 Abstract: The underlying mechanism of cell death in substantia nigra= of Parkinson's disease patients remains unknown. Biochemical changes occurring in substantia nigra in Parkinson's disease (increased iron levels, inhibition of complex I activity and decreased reduced gluta= thione levels; GSH) suggest that oxidative stress and free radical species = may be involved. In particular, a decrease in GSH levels may be an early component of the process, since this also occurs in incidental Lewy = body disease (presymptomatic Parkinson's disease). GSH is lost only from = the substantia nigra in Parkinson's disease and this does not occur in o= ther neurodegenerative disorders of the basal ganglia. GSH loss appears t= o be global throughout the substantia nigra and not localized to either t= he glia or neuronal elements. The activity of enzymes involved in the glutathione cycle are normal with the exception of gamma-glutamyltranspeptidase, the activity of which is increased. Th= is could result in increased removal and degradation of glutathione fro= m cells. Depletion of GSH in rat using L-buthionine-=CDS, R=CD-sulfoxa= mine (BSO) potentiates 6-hydroxydopamine (6-OHDA) toxicity but does not in itse= lf produce degeneration of the nigrostriatal pathway. Oxidative stress = may be a potentially important factor in the degeneration of the substantia= nigra in Parkinson's disease and warrants further investigation into its r= ole in this process. Abstract By: Author Address: Neurodegenerative Diseases Research Centre, King's College London, United Kingdom.