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Sinemet And Fatigue (more) 21 Mar 97: Thanks for your advice, Brian, but you overlook two things I mentioned: (1) The intense pain is in the 'upper' thoracic region, i.e., center of back just below shoulder blades, and not the lumbar region, which one might expect to be affected by lifting,, posture, or shovel work. It appears during mental activity as well, even when leaning back in a comfortable chair. (2) The pain disappears promptly on lying supine (so it is clearly of muscular origin) but just as promptly after taking a Sinemet, even without lying dosn. In fact I can just continue working. As you know, dopamine occurs widely in the body, and not all the levodopa of Sinemet reaches the brain, since the carbidopa isn't 100% effective in preventing its conversion to dopamine. I wonder if there might be some connection in PD, between DA produced in the SN and DA produced outside the brain, elsewhere in the body. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403