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Friends--I'mposting this to the main list rather than CARE in the hope someone
can shed light from personal experiences.
Yesterday Peter had to have an energency extraction of a broken tooth. The
oral surgeon and staff were most accommodating, sensitive to his needs, etc.
and the procedure went well, at 8:00 AM. We were home by 10:00AM, and as
he was still dopey from the anesthetic he slept off and on all day and evening-
-he did take his Sinemet 10/100 every 2 hours as usual,but no extra doses.
He was also on a crash dose (7 AM and 1PM)of Amoxycillin antibio., as he has
mitral valve prolapse, and this is required before any oral surgery.
He was a bit spacey off and on yesterday, due to the anesthetic--and po
also the stress of the situation.  This AM he woke feeling quite normal, took
10/100at 6 AM,8AM, 9:45 (before I left for church) and seemed fine. When
I returned home about 11:30,in time for his next dose, he was in trouble,
said his legs weren't working, couldn't stand to get out of his chair in living
 room.....I gave him the next 10/100 early, at 11:45, dealt with other
problems, and a half hour later he still was too wobbly to stand with my help.
I recalled that this was how he was the time he had to wait for the doc to
discharge him from a day of hospital observation, as the stress of waiting till
9:30PM for the doc really got to him.  On the theory that the stress level may
(like hard exercise has been said to do) cause the Sinemet to not work as well,
 be used up faster, whatever, I persuaded him to take another 10/100 at 12:15,
then sat quietly, played soft music, talked reassuringly. Within a half
hour, he was able to get up and get from the living room to the bathroom with
my help,legs functioning OK!
Here's my question--could it be that stress levels affecthehe way t
Sinemet is used by the body---so that in a highly stressful situation one
might be *undermedicated* even with normal doses?  I should add that Peter has
never had dyskinesia, nor does he have more than very minor resting tremor of
hand when eating. His main problems are bradykinesis,bradyphrenia,and
rigidity. (Plus others too numerous to mention!)
If it seems this is a reasonable deduction from our experience, I can be
prepared to ask neuro to increase his doses during the stressful time when I
will be having surgery in April, and he has chosen to spend three days time in
a local NH, rather than try to cover(for that short time)24 hrs. a day here at
home. Any light that anyone can shed on this subject will be very welcome!

Camilla Flintermann, CG for Peter, 78/7, Oxford,Ohio
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