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My 2 cents worth on Sinemet and (mental or physical) fatigue: Dopamine is ubiquitous in the body, not just the brain. Some is made by the adrenal glands, some is leftover from the levodopa (Sinemet) that fails to get into the brain. I don't know just what function it has outside the brain (neither, judging from replies to my inquiries, do authorities) but I suspect it acts as neurotransmitter in the muscles, and other places. When I'm tired after exertion, fatigue appears as pain in upper back, mostly on one side, around T1 or T2 as far as I can tell. (I don't think it is referred pain of angina). If I advance the Sinemet schedule and take a dose (half a 25/100) the pain and fatigue disaappear within seconds! I'm familiar with "end-of-dose" feelings (lethargy, depression) and when to expect them in normal conditions. That is exactly what is accelerated by any unusual exertion. Bottom line: Exertion increases need for dopamine, inside the brain and (I think) elsewhere. When symptoms caused by exertion appear, moving up the next scheduled Sinemet dose will make them disappear. I should expect that reaction to any other stress, such as a visit to the dentist, would be abolished in the same way. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403 On Sun, 30 Mar 1997, Joao Paulo Carvalho wrote: > Camilla Flintermann wrote: > > > > Friends--I'mposting this to the main list rather than CARE in the hope someone > > can shed light from personal experiences. On the theory that the stress level may > > (like hard exercise has been said to do) cause the Sinemet to not work as well, > > be used up faster, whatever, ........<snipped> > > Here's my question--could it be that stress levels affecthehe way t > > Sinemet is used by the body---so that in a highly stressful situation one > > might be *undermedicated* even with normal doses? I should add that Peter has > > never had dyskinesia, nor does he have more than very minor resting tremor of > > hand when eating. Any light that anyone can shed on this subject will be very welcome! > > > Hi dear lady, > > In my personal experience,emotional undesirable stresses have the most > strong effects on the symptoms with me.Nothing else beats it. > So it would seems logical to think that in such situations one may > reduce the symptoms if increase the normal dosage of Sinemet. > > Let me take the opportunity to tell you that I admire very much your > human kind touch you give to the list that you are in charge and all > contributions you give to this list. > > Best wishes, > > +----| Joao Paulo de Carvalho |------ + > | [log in to unmask] | > +--------| Salvador-Bahia-Brazil |------+ >