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My wife has taken Kemadrin for the past five years. An excellent antidyskinesia medication for her. A planned drug holiday from kemadrine two years ago proved very disturbing. Dyskinesia without it was extreme and we re-started administering it within less than 48 hours. She has never used pergolide so I have no info. on the interaction of the two compounds. Don Summers [log in to unmask] A Shy Drager Caregiver Who Lurks At 10:24 AM 4/4/97 -0500, you wrote: >Hi to you all > >Our Field Officer has requested me to ask for information on the drugs >Pergolide and Kemadrin - their possible benefits and side effects - she is >trying to help her PD client Roger who is having a rough time. > >Case History : Roger - aged 49 - diagnosed PD 1994 > >Passed Medication : Selegiline - two per day for 2 yrs - effective >initially but gradually became less effective. > > Bromocriptine was experimented with but had unacceptable >side effects.Over the passed eight months Roger has been on Pergolide (up >to 4 - 0.25gm tablets per day) and now Kemadrin is being tried - not >encouraging as depression and irrational behavior appears as unpleasant >side effects. > >To date Levadopa has been resisted but maybe necessary soon as Roger's PD >is progressing with intermitent freezing, depression, muscle stiffness and >behavioral problems developing. > >Roger suspects that Permolide & Kemadrin are having negative effects - he >would welcome information about these two drugs &/or experience of them. > >Hope for comments and helpful suggestions > >Jim Caldwell <[log in to unmask]> > >