Hi to you all Our Field Officer has requested me to ask for information on the drugs Pergolide and Kemadrin - their possible benefits and side effects - she is trying to help her PD client Roger who is having a rough time. Case History : Roger - aged 49 - diagnosed PD 1994 Passed Medication : Selegiline - two per day for 2 yrs - effective initially but gradually became less effective. Bromocriptine was experimented with but had unacceptable side effects.Over the passed eight months Roger has been on Pergolide (up to 4 - 0.25gm tablets per day) and now Kemadrin is being tried - not encouraging as depression and irrational behavior appears as unpleasant side effects. To date Levadopa has been resisted but maybe necessary soon as Roger's PD is progressing with intermitent freezing, depression, muscle stiffness and behavioral problems developing. Roger suspects that Permolide & Kemadrin are having negative effects - he would welcome information about these two drugs &/or experience of them. Hope for comments and helpful suggestions Jim Caldwell <[log in to unmask]>