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Hello Patricia and welcome to the list! I have only been on the list for about 3 months but I find it a real source of comfort. I too am a YOPD. I'm 43 and had first symptoms of cramping toes on left foot 11 years ago followed by slight tremor and rigidity on left side. Was diagnosed 8 years ago. Have on/off problems now and again but don't do too bad generally. The worst symptom I have had to deal with has been the depression. Looking back I was having short bouts of depression before any other symptoms appeared but I didn't not realise what it was at the time. Just prior to my diagnosis in 1987 I had severe depression and was put on Amitriptyline and Lithium and that combined with the PD medication (Sinemet) eventually pulled me out of a very serious situation. I still have to take anti-depressants (Clomipramine) which I regulate myself and generally the depression is kept at bay. I would rather have any other PD symptom than depression so I empathise with you and say just hang on in there - I'm sure some other medication must be able to help you. I find it so hard to get information which confirmed to me that it was the PD giving me the depression and when I did find out it was such a relief even though the hard bit was that I couldn't control it. If I can help any more please let me know. You can either e-mail me by the list or direct - [log in to unmask] By the way I am in the UK so I don't know if the anti-depressants I mention are available in the US. Best wishes Susan 43/11 [log in to unmask]