Hi Susan, Just signed up for listserv and can't believe all the mail in the last two hours. I'm not young. 65, but our problems seem much alike. I was on Amatriiptline for a number of years but it made me gain too much weight. Now on Prozac and it works out MUCH better for me. NO DEPRESSION - in fact my very positive frame of mind has been credited with my doing so well in spite of my drug problems. Sinemet gives me some very strange side effects but anything else gives me the same results. One problen my Urologist attributes to PD but I never hear anyone else complain of is incontinence. Real Problem. Constipation not a problem. Does this sound familiar to you or anyone else you may have read about? Just checking [log in to unmask]