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I know this is a bit late, but someone asked about baclofen recently. Found some old notes, as follows: >From J. Neurol, Neurosurg, Psychiatry 1978, A.J. Lees et al, No 41, 707. In PD, in a double-blind crossover study in 12 patients with Parkinsonism talking l-dopa and a decarboxylase inhibitor, baclofen, in an average dose of 45 mg daily, aggravated rigidity and functional disability, but there was a reduction in the pain and the severity of dystonia in 4 patients with morning "off" period dystonia. Adverse effects were common and included: tremors, insomnia, diarrhoea or constipation, hypotension, confusion, drowsiness, nausea & vomiting.