Hi, everyone, Thank you, Barbara, for your welcome and for the info on how to post a message, etc. My husband is the person with PD, diagnosed in Jan. His neurologist started him on Sinemet CR, 1/2 tab, and although it gave Bob (my husband) gas and about twice a week, diarrhea, he did very well otherwise. Then the dr. upped the dose to 1 whole tab and the gas/diarrhea got much worse. We had reported these symptoms to the dr., by the way. Fri. the dr. suggested going back to 1/2 Sinemet CR and going off it entirely in 2 weeks, and had him start on Permax Mon. Not a good idea. Bob had terrible diarrhea Mon. night several times. I called the dr. Tues. morning and said, No more Permax. Ever. Bob also takes Eldepryl, one after breakfast, one after lunch, and thinks he's doing fine with that and does not think it's causing any gastric trouble. Yesterday the dr. called to prescribe lomotil for the gastric trouble. It's better than over-the-counter stuff, I guess. Bob has tried stopping all sorts of food and beverages (caffeine-free, sugar-free Coke is his only vice), and nothing has made any difference. I know most PD people complain of constipation, but that's not Bob's problem. We'd both be really grateful if anyone has any suggestions. Please write me at: [log in to unmask] (or if you're on aol, just use the first 7 letters). Thanks so much for any help. I enjoyed reading everyone's notes and look forward to being "connected." Bob's tremor is better than it was, but too severe for him to manage the computer, which is why you're hearing from me instead of from him. Thanks, everyone. Delda White ([log in to unmask])