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my name is Jerry Starr. I am a pharmacist from Dayton, Oh and a new member of this list. I would like to try and clear up a few matters that have been brought up today. 1. The sinamet dosage that was mentioned (3x25/100 and 1x 50/200-sr at bedtime is a large dose, but not abnormally large. I would not like to see it go any higher. There is a new dopamine agonist (as is permax) that has just been approved by the FDA called Pramapexole(Pharmacia & Upjohn Co.). This drug may be more effective than Permax and can be tried in place of Permax.(this is just a suggestion to ask your doctor) 2. Aricept is a new drug similar to Cognex for alzheimers. It has the advantage of lower toxicity, and can be taken once a day. 3. Many other things can cause pain in the chest or arm, but these symptoms should always be checked to rule out a heart attack. 4. Generic Sinamet is available in immediate release formulation (but not in the SR form), and should save you money. --If there are other questions, please contact me. Jerry Starr Rph. (jhstarr@concentric net) Jerry Starr, Rph. ([log in to unmask])