Allan-My husband 75/11 (or 11/75?) has been on the following regimen for several years. -Sinemet 50/200 fourXdaily -Permax .25mg fourXdaily with an extra 1/2 in first and 3rd dose Elderpryl 5mg 8am and 12 noon Sinemet 25/100 (1/2 tablet on arising and in between his every four hour during the day 50/200) We call them 'kickers'. Those keep him going until the next 50/200 is due. His antioxidants are Vit C 1000mg 1Xday Vit E 800mg 2Xday(2 - 400 caps each time)