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I've mentioned before that I've been taking pramipexole for three years with generally favorable results, though my off/on problems are still pretty persistent and eating anything interferes with my sinemet (and therefore the pramipexole, which is a helper drug.) Reseachers at WashU are studying tolcapone at the same time, and feel it is a more effective drug. Tolcapone is due to be approved by the end of the year and should be on the market shortly after pramipexole. I'd like to take them both, but their interaction hasn't been determined yet. Given a choice, I'll probably opt for the tolcapone. I've been told I'll have to take a few days to acclimate to the new drug, since it requires a drastic adjustment of sinemet. Either way, we have two promising new drugs that should help those of us who've reached the point where sinemet is less effective than it used to be. pine`