 |
 |
---------- Forwarded message ---------- ---- Article ------- Newsgroups: alt.support.mult-sclerosis From: Irwin Mortman <[log in to unmask]> From: [log in to unmask] Thought you might find this of interest Does cryptic gluten sensitivity play a part in neurological illness? Medline? Medlars UID 96169974 Lancet Vol. 347 no. 8998 pp. 369-71 Type: JOURNAL ARTICLE CAS Registry/EC Number:?0 (IgA) CAS Registry/EC Number:?0 (IgG) CAS Registry/EC Number:?9007-90-3 (Gliadin) Language:?Eng Country:?ENGLAND Journal Code:?L0S Indexing Priority:?1 Journal Subset:?A Journal Subset:?M Journal Subset:?X MeSH Headings: Biopsy Case-Control Studies Celiac Disease/*complications/diagnosis Comparative Study Duodenum/pathology Enzyme-Linked Immunosorbent Assay Female Gliadin/*immunology Human IgA/analysis IgG/analysis Male Middle Age Nervous System Diseases/*etiology/immunology Predictive Value of Tests DATE: 1996 Feb 10 Abstract BACKGROUND: Antigliadin antibodies are a marker of untreated coeliac disease but can also be found in individuals with normal small-bowel mucosa. Because neurological dysfunction is a known complication of coeliac disease we have investigated the frequency of antigliadin antibodies, as a measure of cryptic gluten sensitivity, and coeliac disease in neurological patients. METHODS: Using ELISA, we estimated serum IgG and IgA antigliadin antibodies in 147 neurological patients who were divided into two groups. There were 53 patients with neurological dysfunction of unknown cause despite full investigation (25 ataxia, 20 peripheral neuropathy, 5 mononeuritis multiplex, 4 myopathy, 3 motor neuropathy, 2 myelopathy). The remaining 94 patients were found to have a specific neurological diagnosis (16 stroke, 12 multiple sclerosis, 10 Parkinson's disease, 56 other diagnoses) and formed the neurological control group. 50 healthy blood donors formed a third group. FINDINGS: The proportions of individuals with positive titres for antigliadin antibodies in the three groups were 30/53, 5/94, and 6/50 respectively (57, 5, and 12%). The difference in proportion between group 1 and the combined control groups was 0.49 (95% CI 0.35-0.63). Distal duodenal biopsies in 26 out of 30 antigliadin-positive patients from group 1 revealed histological evidence of coeliac disease in nine (35%), non-specific duodenitis in ten (38%), and no lesion in seven (26%) individuals. INTERPRETATION: Our data suggest that gluten sensitivity is common in patients with neurological disease of unknown cause and may have aetiological significance. Hadjivassiliou M Gibson A Davies-Jones GA Lobo AJ Stephenson TJ Milford-Ward A Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK. 1996 960822 Irwin Mortman Voice 513-891-7359 FAX 513-891-8186 Cincinnati, OH