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Since my pallodomity I have had hard time with meds. I can only take 3 25/100 a day and can't find an antidepressant that does not interact to cause stiffness after two or three doses. I am thankful for the fuller range of motion, but I am limited to mobility because I got relief on the left side and the right side is now beginning to worsen so I need the sinemet for mobility. Any one else have a similar problem. Did it last long after surgery? I am just six weeks into the healing from surgery on March 6. I am depressed and need my meds tohelp me pull myself up. Patricia from Texas 51/7