Ivan, Very! Very! Interesting! My way of thinking was that Parkinsons
was an metabolic disorder, it was once thought that PKU was genetically
inherited, which causes an enzyme to behave poorly. Now we know that
phenylalanine hydrozylation reaction is the end result of a number of
components: the enzyme, the cofactor (tetrahydrobiopterin), plus the
enzymes and genes for the production and maintenance of the cofactor.
I was beginning to wonder why reduced glutathione, NADHph , etc. were
notably for diabetics, yet my father was beneifiting from these.
On the reverse side, NAC had a negative impact, increased tremor,
again noted as off limits to diabetics.
Like PKU, and unlike PKU, I believe that something is going haywire
with certain enzymes(aminos) like Phenylalanine, Tyrosine, Nadph+H,
glutathione, just to mention a few. Or perhaps only one of these, Hmmm?
Thanks for you study, Ivan, my grandmother did have diabeties.
Linda Forrest's Mom
In-reply-to: Your message dated "Sat, 19 Apr 1997 01:04:41 -0400"
<[log in to unmask]>
>Hi Listmembers,,
> Hello again from lighthouse and lobster-land! I've finally waded
>through 400 messages upon returning to Maine from a week in Florida, and,
>I have a QUESTION that keeps coming up, which if answered by a large
>sample (100 or more) of Listmembers worldwide, might help to unveil
>aspects of the mystery of the GENES involved in Parkinson's Disease.
> DO YOU HAVE A DIABETIC RELATIVE??
> My older brother is a young onset diabetic, and I am a young onset
>PWP.
>And it turns out that 17 of 21 PWP's I initially surveyed in MAINE have a
>diabetic relative!! That's an 81% incidence in this small sample of
>PWP's!
> In the human body, some of our dopamine is converted into
>adrenaline, and adrenaline is the inhibitor of insulin. So our dopamine
>supply and insulin levels are closely biochemically linked.
> If there is a GENE which regulates the human normal tyrosine to
>dopamine to adrenaline conversion pathway, that gene, if mutated or
>somehow dysfunctional, might cause either Parkinson's (dopamine
>deficiency), or diabetes (insulin deficiency) to develop. AND, we might
>expect to observe more diabetics in PWP families.
> 17 of 21 PWP's in my survey in MAINE have a diabetic relative in
>their family!! That incidence of 81% is WAY TOO HIGH to be random.
> I'm just a PWP, not a high-stakes geneticist.
> But it seems to me that this HIGH FREQUENCY of diabetics in our
>families in Maine suggests that there IS a genetic explanation for
>Parkinson's.
> I think that if a large sample (100 or more) of Listmembers would
>send a BRIEF comment to the list, we could get a better understanding of
>the gene or genes involved in causing PD. This might help us figure out
>the chemistry of CURING PD.
> So, my question is, DO YOU HAVE A DIABETIC RELATIVE???
> PWP's and CG's, PLEASE send a brief response. Comments on the
>GENETIC theory I have put out here are of course more than welcome!!.
>Ivan Suzman 47/10 [log in to unmask]
>Portland, Maine
