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I am a 50 year old with PD for four years,on meds for one and a half years, having big problem with end of dose wearing off and dystonia, especially in the evening and first thing in am. I have not had good luck with Eldepryl, Permax,(side effects intolerable). I am currently using Sinemet 25/100 ; one Sinemet CR plus 0ne-two regular Sinemet at 7 am, then about one and a half to two regular Sinemet every three tofour hours. Any suggestions??? Also any one had problems with MSG induced dystonia after Chinese food???