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Bob I am 51 and have PD 13yrs. If I have gotton a good nights sleep I can usually delay any med. for 1-2 hrs; then I taker 1/2 25/100 (jump start) with 1 CR. After that 1 CR @ 3 1/2 to4 hr. intervals with 1/2 permax (also permax with jump start). plus 1 eldepryl/day. More than 1/2 permax @ 4 hrs. makes me hyper. (there other meds. like permax ask your doctor. Regular sinment has quick start but short duration CR should last 3-5. CR followed by CR with proper lead time might help wear off ( about 1 hr. lead time for CR 15-20 min for Regular 25/100. hope I have helped in some way. Questions? my e-mail is [log in to unmask]