Bob Leet <[log in to unmask]> wrote: snip <<< he's managing PD with one sinemet cr (50/200) 3x daily; i.e. 6AM, noon, and 10PM. He will also occasionally take a sinemet 10/100 on a real bad day, or on a day when he needs an extra boost (like holidays or while travelling). He tries to limit taking the extra sinemet to no more than once or twice a week, but will sometimes go a couple weeks w/out. He gets up early and will usually work out in the garage until early afternoon - after that he's usually too stiff to continue. The garage is now really a workshop - he just finished building an elaborate array of shelves, tables and drawers - and just put in a new bandsaw, planer and jointer with their tax refund. He's been working with wood all his life, but because of us kids he never had enough money to put together a decent shop. Now he is "ready to take orders" from us kids and friends. When I think of his forward moving - damn the PD - full speed ahead attitude it brings tears to my eyes. Not pity - pride. snip Questions: 1) Itching all over can be a real problem sometimes. He's convinced it has something to do w/ PD or meds or both. He's tried Eucerin, Aveeno, Tinactin, Cortisone-5 cream, and Goldbond powder. Only Goldbond seems to offer any relief. Any suggestions? 2) What are the ups and downs of becoming a research participant. He is excited about GPI-1046 and has no idea how to find out who to contact to express interest. Would he have to surrender his normal meds? Insurance and expense issues are also a concern.>>>>> Bob, The first comment I will make is that sinemet CR 50/200 at 6 and noon will be most efffective from about 7:30 to 11:30 and about 1 to 5: then, there is a long wait until 10 PM. 2nd, the attitude Don has is just right imo. Itching has not been frequently mentioned. I have skin problems that have rashy red spots that are worsened by solanacea (potatoes, tomatoes, peppers, etc) and somewhat by strawberries and chocolate. Itching, sore, touchy, flaky thinning skin and sun-sensitivity. Believe my problems started many years ago when I overdid the eating of fresh tomatoes and peppers for a month that resulted in a rash over my whole back that seemed to go down my arms and also was affectig my ankles for some time. May be some allergy to certain wood dusts is part of what I have noted a time or two when I did sanding. Or solvents and adhesive solvents or chemicals. As to trying the potential GPI-1046, I doubt that humans will not get involved in testing before 5 years from now. best wishes. visit my home page for some more about medicating with levodopa. URL is bottom signature line. -- ron 1936, dz PD 1984 Ridgecrest, California Ronald F. Vetter <[log in to unmask]> http://www.ridgecrest.ca.us/~rfvetter